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I am a New Zealand registered nurse and nutritionist (Grad Cert Sci: nutrition, Massey Univ). I am a Certified Zone Instructor, and have worked teaching Zone diet principles to hundreds of clients over the last 10 years. More recently after finding that eating Paleo food choices was the "icing on the cake" health wise, I have become a Paleo enthusiast and teacher. Follow me on twitter @juliannejtaylor

Bone Marrow Transplants and the life saving effect of omega 3

About 6 years ago my youngest brother, a doctor (emergency medicine), husband, and father of 4 was diagnosed with acute myeloid leukemia. This is cancer of the blood – or rather theĀ  blood making stem cells in the bone marrow. He had a really nasty aggressive type, and a bone marrow transplant was recommended. This required killing off all his bone marrow with chemotherapy and then giving him healthy bone marrow stem cells, from a donor with a tissue type matched as closely as possible.

Here we all are - in the 1960's, my little brother to the right, I'm the oldest on the left.

There are 4 of us siblings, so we healthy three had our tissue types done to see if they matched. Unfortunately none of us did, in fact they were all so different – it looked like we were unrelated.

This meant an unrelated donor had to be found. Within a few days one was found in Melbourne Australia. The tissue type was a very good match. However this procedure called MUD or Matched Unrelated Donor, is not without risk. When one has an organ transplant, there is always the risk of rejection, and immuno-suppressant drugs are taken for the rest of ones life to decrease this rejection risk. When you have a stem cell transplant, you are changing your blood, and the blood contains immune cells. There is a risk that if not matched closely enough, the newly transplanted material attacks the transplant recipient’s body. This is called Graft-versus-host disease (GVHD) Rates of GVHD vary from between 30 – 40% among related donors and recipients to 60 – 80% between unrelated donors and recipients. Strong immuno-suppressant drugs are required to stop this attack. You cannot simply remove the organ like you can a kidney if it is rejected, your very blood rejects you and and all your organs, and severe GVHD leads to death.

Not a happy thought. As you can imagine – I had my head buried in Pubmed looking for any supplement / diet etc. that might help my brother survive.

I found this study “Oral eicosapentaenoic acid for complications of bone marrow transplantation”

The ‘systemic inflammatory response syndrome’ (SIRS) may represent the underlying cause of complications after bone marrow transplantation (BMT). This study was conducted to determine whether blocking the etiologic factors of SIRS could improve the complications of BMT. Sixteen consecutive patients with unrelated donors were allocated alternately to two groups.

Seven patients received 1.8 g/day of eicosapentaenoic acid (EPA) orally from 3 weeks before to about 180 days after transplantation, while nine patients did not. These two groups were compared with respect to complications, survival, and various cytokines and factors causing vascular endothelial damage. All seven patients receiving EPA survived and only two had grade III graft-versus-host disease (GVHD).

Among the nine patients not receiving EPA, three had grade III or IV GVHD. In addition, thrombotic microangiopathy developed in four patients and cytomegalovirus disease occurred in four. Five patients died in this group.

The levels of leukotriene B4, thromboxane A2, and prostaglandin I2 were significantly lower in patients receiving EPA than in those not receiving it (all P < 0.01). Cytokines such as tumor necrosis factor-alpha, interferon-bold gamma, and interleukin-10 were also significantly decreased by EPA (P < 0.05), as were factors causing vascular endothelial damage such as thrombomodulin and plasminogen activator inhibitor-1 (P < 0.05). The survival rate was significantly higher in the group given EPA (P < 0.01). EPA significantly reduced the complications of BMT, indicating that these complications may be manifestations of the systemic inflammatory response syndrome.

Bone Marrow Transplantation (2001) 28, 769-774.

WOW, of 7 in a group that takes EPA Omega 3, there is less inflammation and GVHD and no deaths, and in the group not taking it 5 of 9 die!

This study too from the same group:

Oral eicosapentaenoic acid for acute colonic graft-versus-host disease after bone marrow transplantation.

Abstract

We investigated whether pretreatment with eicosapentaenoic acid, an inhibitor of leukotriene (LT) B4, could ameliorate acute colonic graft-versus-host disease (GVHD) after bone marrow transplantation (BMT). Seventeen patients undergoing unrelated BMT were divided into two groups, with eight patients receiving eicosapentaenoic acid and nine not receiving it. The grade of GVHD after transplantation was compared with that estimated from the pretransplantation LTB4 level. The levels of LTB4 and several cytokines were also monitored. The actual grade of GVHD was lower than that estimated from LTB4 levels in three of the eight patients from the treated group, and there was a significant difference between the treated and untreated groups (p < 0.05, chi 2 test). The levels of LTB4, tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma) were all significantly lower in the treated group (p < 0.05, Student’s t-test). These findings suggest that eicosapentaenoic acid may ameliorate acute colonic GVHD when administered from before BMT

I showed this to my brother and gave him a bottle of Dr Sears OmegaRx liquid fish oil. (High strength, high purity and no oxidation, batch tested, I didn’t want to take any risks here with cheap fish oil) By the way omega 3 is also shown to make chemotherapy more effective. “Nutritional intervention with omega-3 fatty acids enhances tumor response to anti-neoplastic agents”. So he started taking it, through the nauseating chemo, the days in the transplant unit, before and after his transplant.

Following his Bone Marrow Transplant, he only suffered a very low level of GVHD, and after a few months was able to go back to work part time, and eventually he was also able to discontinue his immuno-suppressant medication.

It is now around 6 years post BMT, although he gets tired and has some mild symptoms, he is able to work part time in the hospital emergency department, and he is fine. I wrote to share this study as without the benefit of it, and taking the fish oil, I’m not sure my brother would have come through this as well as he did. (It seems even the doctors in the transplant unit didn’t know about it).

Vitamin D may also be an important – it is highly likely that a leukemia patient has low vitamin D levels – a crucial pro-hormone for immune function:

Vitamin D deficiency, autoimmunity, and graft-versus-host-disease risk: Implication for preventive therapy

I hope that others might benefit from this knowledge.

Dr Sears Omega Rx can be bought in New Zealand (New Zealand and Australian customers) here.

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12 Responses to “Bone Marrow Transplants and the life saving effect of omega 3”

  1. Larry #

    God Bless You. Your brother is very fortunate to have a sister such as you.

    May 13, 2011 at 12:02 pm Reply
  2. scott #

    Hi Julianne: Great post. I agree, your brother is very lucky to have you as a sister. Have there been any follow up studies since 2001?

    May 16, 2011 at 5:59 pm Reply
    • Hi Scott,
      I’m not sure. I can’t find any more: This 2006 review states “Individual studies of EPA supplementation as capsules showed improvements in survival, complications and inflammatory markers in patients undergoing bone marrow transplant (BMT).” http://www.ncbi.nlm.nih.gov/pubmed/16327975
      They reference the above study and this one. -I’m not sure if this was another study or another take on the same one: Oral eicosapentaenoic acid for acute colonic graft-versus-host disease after bone marrow transplantation. http://www.ncbi.nlm.nih.gov/pubmed/12512229

      May 16, 2011 at 9:09 pm Reply
  3. What a great story, Julianne. Good things happen when people take their health into their own hands.

    May 16, 2011 at 10:30 pm Reply
  4. Geo #

    Julianne,
    Thank you for sharing this info. I have a friend who just had an allo transplant from an unrelated donor. She would like to take the EPA (Dr. Sears OmegaRX capsules). According to the site the primary fish oil used to make the oil is anchovy. Do you have any opinion or concerns about the source materials that the oil is made from. Also, did your brother take the specified amount used in the study “600 mg of EPA 3 times daily”?

    Thank you again for bringing sharing as I feel this information will help more people than you know.
    I found your site first and then the reports.

    August 1, 2011 at 5:46 am Reply
    • My brother used the liquid omega Rx and took a teaspoon a day – approx equal to 4 caps, and gives 2500mg EPA+DHA. I don’t have any concerns about the source of fish oil.

      Your friend could take 2 capsules of omegaRx 3 times a day

      Best wishes to your friend

      August 1, 2011 at 7:48 am Reply
  5. Very interesting for me too. I had a transplant 24 years ago. I was 16 and my sister (donor) was only four. I am now running in a marathon to raise money for transplants. I’m blogging about my experience on marathonformarrow.org

    January 15, 2012 at 11:14 pm Reply
    • Thanks for visiting. Good luck with the marathon and fundraising.

      January 16, 2012 at 12:35 am Reply
  6. Luis #

    Hi Julianne! I need your help . I will have a BMT soon. Do you know where can i get it? I am from Spain. How should i take it? Which Product of course?!

    thank you

    April 20, 2012 at 11:04 am Reply
    • I get it from USA http://www.zonediet.com
      Omega RX

      If you cant get it from the USA – buy a good quality omega 3 locally.

      All the best
      Julianne

      April 20, 2012 at 2:10 pm Reply
      • Luis #

        which one did your brother took? and how they took? did u talk with it to your bone marrow team?

        April 20, 2012 at 10:25 pm Reply

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