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Author Information

I am a New Zealand registered nurse and nutritionist (Grad Cert Sci: nutrition, Massey Univ). I am a Certified Zone Instructor, and have worked teaching Zone diet principles to hundreds of clients over the last 10 years. More recently after finding that eating Paleo food choices was the "icing on the cake" health wise, I have become a Paleo enthusiast and teacher. Follow me on twitter @juliannejtaylor

Paleo a fad diet? Not so fast: Paleo diet clinical studies

Clinical Studies

Lindeberg S, et al. A Palaeolithic diet improves glucose tolerance more than a Mediterranean-like diet in individuals with ischaemic heart disease. Diabetologia, 2007.

Osterdahl M, et al. Effects of a short-term intervention with a paleolithic diet in healthy volunteers. European Journal of Clinical Nutrition, 2008.

Jonsson T, et al. Beneficial effects of a Paleolithic diet on cardiovascular risk factors in type 2 diabetes: a randomized cross-over pilot study. Cardiovascular Diabetology, 2009.

Frassetto, et al. Metabolic and physiologic improvements from consuming a paleolithic, hunter-gatherer type diet. European Journal of Clinical Nutrition, 2009

Ryberg, et al. A Palaeolithic-type diet causes strong tissue-specific effects on ectopic fat deposition in obese postmenopausal women. Journal of Internal Medicine, 2013.

Tommy Jönsson et al Subjective satiety and other experiences of a Paleolithic diet compared to a diabetes diet in patients with type 2 diabetes  Nutr J. 2013; 12: 105.

Tommy Jönsson et al A paleolithic diet is more satiating per calorie than a mediterranean-like diet in individuals with ischemic heart disease Nutr Metab (Lond) 2010; 7: 85.

Kristine A Whalen et al. Paleolithic and Mediterranean Diet Pattern Scores Are Inversely Associated with Biomarkers of Inflammation and Oxidative Balance in Adults J Nutr. 2016 Jun; 146(6): 1217–1226

Kristine A Whalen et al. Paleolithic and Mediterranean Diet Pattern Scores and Risk of Incident, Sporadic Colorectal Adenomas Am J Epidemiol. 2014 Dec 1; 180(11): 1088–1097.

Julia Otten et al. Effects of a Paleolithic diet with and without supervised exercise on fat mass, insulin sensitivity, and glycemic control: a randomized controlled trial in individuals with type 2 diabetes Diabetes Metab Res Rev. 2017 Jan; 33(1):

Zsófia Clemens et al Childhood Absence Epilepsy Successfully Treated with the Paleolithic Ketogenic Diet Neurol Ther. 2013 Dec; 2(1-2): 71–76.

Angela Genoni et al, Cardiovascular, Metabolic Effects and Dietary Composition of Ad-Libitum Paleolithic vs. Australian Guide to Healthy Eating Diets: A 4-Week Randomised Trial Cardiovasc Diabetol. 2009; 8: 35.

Angela Genoni et al, Compliance, Palatability and Feasibility of PALEOLITHIC and Australian Guide to Healthy Eating Diets in Healthy Women: A 4-Week Dietary Intervention Nutrients. 2016 Aug; 8(8): 481.

Maelán Fontes-Villalba et al Palaeolithic diet decreases fasting plasma leptin concentrations more than a diabetes diet in patients with type 2 diabetes: a randomised cross-over trial Cardiovasc Diabetol. 2016; 15: 80.

Maelán Fontes-Villalba et al, A healthy diet with and without cereal grains and dairy products in patients with type 2 diabetes: study protocol for a random-order cross-over pilot study – Alimentation and Diabetes in Lanzarote -ADILAN Trials. 2014; 15: 2. Published online 2014

Lynda A Frassetto et al,Established dietary estimates of net acid production do not predict measured net acid excretion in patients with Type 2 diabetes on Paleolithic-Hunter-Gatherer-type diets Eur J Clin Nutr. 2013 Sep; 67(9): 899–903.

Irish AK et al Randomized control trial evaluation of a modified Paleolithic dietary intervention in the treatment of relapsing-remitting multiple sclerosis: a pilot study Dovepress. 4 January 2017 Volume 2017:7 Pages 1—18

Babita Bisht et alA Multimodal Intervention for Patients with Secondary Progressive Multiple Sclerosis: Feasibility and Effect on Fatigue J Altern Complement Med. 2014 May 1; 20(5): 347–355.

Konijeti GG  Efficacy of the Autoimmune Protocol Diet for Inflammatory Bowel Disease (Autoimmune paleo protocol) 2017 Aug 29.

Inge Boers et al, Favourable effects of consuming a Palaeolithic-type diet on characteristics of the metabolic syndrome: a randomized controlled pilot-study Lipids Health Dis. 2014; 13: 160.

Caroline Mellberg et al, Long-term effects of a Palaeolithic-type diet in obese postmenopausal women: a two-year randomized trial Eur J Clin Nutr. 2014 Mar; 68(3): 350–357.

Lynda A Frassetto et al,  Established dietary estimates of net acid production do not predict measured net acid excretion in patients with Type 2 diabetes on Paleolithic-Hunter-Gatherer-type diets Eur J Clin Nutr. 2013 Sep; 67(9): 899–903.

Rachael W. Taylorm et al, Determining how best to support overweight adults to adhere to lifestyle change: protocol for the SWIFT study BMC Public Health. 2015; 15: 861

Anne Hammarström et al, Experiences of barriers and facilitators to weight-loss in a diet intervention – a qualitative study of women in northern Sweden  (Paleolithic vs Nordic diet study) . 2014; 14: 59.


David C. Klonoff The Beneficial Effects of a Paleolithic Diet on Type 2 Diabetes and Other Risk Factors for Cardiovascular Disease . 2009 Nov; 3(6): 1229–1232.

Eric W Manheimer et al Paleolithic nutrition for metabolic syndrome: systematic review and meta-analysis Am J Clin Nutr. 2015 Oct; 102(4): 922–932.

Theoretical papers

Lindeberg, S Paleolithic Diets as a Model for Prevention and Treatment of Western Disease  2012 Mar-Apr;24(2):110-5.

Cordain L, et al Modulation of immune function by dietary lectins in rheumatoid arthritis. (Theoretical paper on the effect of lectins from cereal grains and legumes on rheumatoid arthritis) 2000 Mar;83(3):207-17.

Ian Spreadbury Comparison with ancestral diets suggests dense acellular carbohydrates promote an inflammatory microbiota, and may be the primary dietary cause of leptin resistance and obesity Diabetes Metab Syndr Obes. 2012; 5: 175–189.

Karin de Punder, Leo Pruimboom The Dietary Intake of Wheat and other Cereal Grains and Their Role in Inflammation Nutrients. 2013 Mar; 5(3): 771–787.

Tommy Jönsson et al Agrarian diet and diseases of affluence – Do evolutionary novel dietary lectins cause leptin resistance? BMC Endocr Disord. 2005; 5: 10.

Papers that include paleo diet associated with clinical results

Ladan Afifi et al, Dietary Behaviors in Psoriasis: Patient-Reported Outcomes from a U.S. National Survey Dermatol Ther (Heidelb) 2017 Jun; 7(2): 227–242.

Stephen D. Anton Effects of Popular Diets without Specific Calorie Targets on Weight Loss Outcomes: Systematic Review of Findings from Clinical Trials Nutrients. 2017 Aug; 9(8): 822.

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