Sorry this is just a quick cut and paste of information on a really important topic. I’m buckling down to get an assignment finished which I hope will lead to some interesting blog posts. I’m looking at studies where micronutrients are given to those who are obese and the effect on fat mass and inflammation.
In a nutshell:
1. Overweight and obese have higher markers of inflammation
2. They have many nutrient deficiencies, it is not clear whether the nutrient deficiencies contribute to weight gain or weight gain contributes to nutrient deficiencies, likely both.
3. I’m looking specifically at double blind intervention studies where a nutrient or nutrients are given and its effect on fat mass and inflammation. I.e. does taking vitamins or minerals reduce fat mass and inflammation in overweight people?
Back to non celiac gluten sensitivity
This is a sensitivity to gluten in those that test negative for celiac disease. Many doctors are unaware that this exists. I know this because I have seen a number of clients who have gut issues such as IBS, foggy brain, aches and pains that go when gluten is removed. When they tell their doctor, they say something like – “that is great that it works for you, but you are not celiac. Not sure why this is”
This paper has just been released, it covers the topic well, and is free full text.
Here is an excerpt:
4. Clinical Picture and Natural History
NCGS is characterized by symptoms that usually occur soon after gluten ingestion, disappear with gluten withdrawal and relapse following gluten challenge, within hours or few days. The “classical” presentation of NCGS is a combination of IBS-like symptoms, including abdominal pain, bloating, bowel habit abnormalities (either diarrhea or constipation), and systemic manifestations such as “foggy mind”, headache, fatigue, joint and muscle pain, leg or arm numbness, dermatitis (eczema or skin rash), depression, and anemia [2,15]. When seen at the specialty clinic, many NCGS patients already report the causal relationship between the ingestion of gluten-containing food and worsening of symptoms. In children, NCGS manifests with typical gastrointestinal symptoms, such as abdominal pain and chronic diarrhea, while the extra-intestinal manifestations seem to be less frequent, the most common extra-intestinal symptom being tiredness . During the last decade, several studies suggested a relationship between NCGS and neuropsychiatric disorders (see following paragraphs). While it is undisputable that in some cases the positive effect of gluten withdrawal can be explained by a placebo effect, this is not the case in true NCGS. In a double-blind randomized placebo-controlled study design, Biesiekierski et al. found that IBS-like symptoms of NCGS were more frequent in the gluten-treated group (68%) than in subjects on placebo (40%) .
This graph below comes from the Biesiekierski study which clearly shows the difference in symptoms eating gluten free bread or gluten containing bread:
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